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免疫佐剂CpG ODN说明-艾美捷CpG ODN 方案

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发布日期:2022/12/16 16:55:05

更新日期:2022/12/16 16:55:05

详细内容

 免疫佐剂(immunoadjuvant,又称非特异性免疫增生剂,其本身不具有抗原性,但同抗原一起或者预先注射到机体后,能非特异性地改变机体对该抗原的特异性免疫应答。1925Ramon先发现在疫苗中加入某种其他物质可以提高抗原的特异性免疫应答,后来此种物质被命名为免疫佐剂,随后各种各样的不同物质被用做免疫佐剂,从而大大提高了疫苗的保护性效力。免疫佐剂在增强疫苗的免疫作用中发挥了大的功能,并且经历了从天然佐剂到人工佐剂的演变。

 

免疫佐剂目有多种种类,可分为传统免疫佐剂、细胞因子免疫佐剂、天然来源免疫佐剂和新型免疫佐剂。

 

CpG-ODN作为免疫佐剂的应用:

CpG-ODN能协同抗原刺激特异性B细胞和T细胞的分化,可作为高效的疫苗佐剂。CpG-DNA能同时增强体液免疫应答和细胞免疫应答,尤其对细胞免疫应答具有更突出的增强作用。CpG-ODN几乎对所有蛋白质抗原和灭活疫苗具有佐剂作用,而且在与其它佐剂合用时还可弥补其他佐剂诱导Th2型免疫应答的缺陷。

 

CpG-DNA安全有效的佐剂特性,使其成为佐剂域的研究热点,特别是能使灭活疫苗及可溶性蛋白抗原等诱导的Th2反应向Th1反应转换,增加对疾病的保护性。

 

CpG-ODN可作为免疫治疗药物

CpG序列在动物体内能激发强烈的Th1相关的免疫反应,抑制Th2相关免疫反应。利用这些特点,有可能用CpG-DNA治疗过敏反应如哮喘及Th2相关的自体免疫疾病。

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艾美捷CpG ODN 寡聚脱氧核苷酸特点:

1、无内毒素水,ddWater

2、除对照产品外,产品内均已提供阴性对照

3、无菌,冻干粉,内毒素<0.002EU/?g

4BULK:可用于体内实验  

 

艾美捷CpG ODN Cell文章鉴赏

IF=66.8, Systematic discovery of TLR signaling components delineates viral-sensing circuits ,Cell

 

艾美捷CpG ODN 更多发表文章:

Ban, T., Kikuchi, M., Sato, G.R. et al. Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nat Commun12, 4379 (2021).

Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils: T. Reif, et al.; Cell Rep. Med. 2, 100317 (2021)

Homeostatic and Pathogenic Roles of GM3 Ganglioside Molecular Species in TLR4 Signaling in Obesity: H. Kanoh, et al.; EMBO J. 39, e101732 (2020)

Murakami, Yuki, et al. "Increased regulatory B cells are involved in immune evasion in patients with gastric cancer." Scientific reports 9.1 (2019): 1-9.

Maatouk, L., Compagnion, AC., Sauvage, MA.Cd. et al. TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons. Nat Commun9, 2450 (2018).

Okamura, T., Sumitomo, S., Morita, K. et al. TGF-β3-expressing CD4+CD25?LAG3+ regulatory T cells control humoral immune responses. Nat Commun6, 6329 (2015).

Chevrier, Nicolas et al. "Systematic discovery of TLR signaling components delineates viral-sensing circuits". Cell vol .147,4 (2011): 853-67.

Larson, S. R., et al. "Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens." Cell Death & Differentiation 23.6 (2016): 997-1003.

Jia, Xianxian, et al. "CCK 8 negatively regulates the TLR 9induced activation of human peripheral blood p DC s by targeting TRAF 6 signaling." European Journal of Immunology 44.2 (2014): 489-499.

TLR9-signaling is required for turning retinoic acid into a potent stimulator of RP105 (CD180)-mediated proliferation and IgG synthesis in human memory B cells: A. Eriksen, et al.; Cell. Immunol. 279, 87 (2012)

Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1: S. Keck, et al.; J. Immunol. 184, 5809 (2010)

Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals: A.J. Tyznik, et al.; J. Immunol. 181, 4452 (2008)

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