Promotes microtubule assembly ａnd stability, ａnd might be involved in the establishment ａnd maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Specifications

Target Protein Phospho-Tau (Thr231)

Clonality Polyclonal

Storage/Stability -20°C/1 year

Application WB,ELISA

Recommended Dilution WB 1:500-1:2000

Concentration 1 mg/ml

Reactive Species Human,Mouse,Rat

Host Species Rabbit

Immunogen A synthesized peptide derived from human Tau around the phosphorylation site of Threonine 231

Specificity Phospho-Tau (Thr231) Antibody detects endogenous levels of Tau only when phosphorylated at Threonine 231

Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- ａnd non-phospho-peptide affinity columns.

Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt

Gene Name MAPT

Accession No. P10636

Alternate Names AI413597; AW045860; DDPAC; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1; MAPT; MAPTL; MGC134287; MGC138549; MGC156663; Microtubule associated protein tau; Microtubule associated protein tau isoform 4; Microtubule-associated protein tau; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; Paired helical filament-tau; PHF tau; PHF-tau; PPND; PPP1R103; Protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; TAU; TAU_HUMAN; Tauopathy ａnd respiratory failure, included;

促进微管组装和稳定性，并可能参与神经元性的建立和维持。C末端结合轴突微管，而N末端结合神经质膜成分，这表明tau作为两者之间的连接蛋白起作用。轴突性由中心体定义的细胞体结构域中的TAU/MAPT定位（在神经元细胞中）预先确定。短亚型允许细胞骨架的可塑性，而较长的亚型可以优先在其稳定中发挥作用。

艾美捷磷酸化-Tau（Thr 231）抗体#GBS-ITA0919-100u规格：

目标蛋白 磷酸Tau（Thr231）

克隆性 多克隆

储存/稳定性 -20°C/1 年

应用 WB，酶联免疫吸附法

推荐稀释度 WB 1：500-1：2000

浓度 1毫克/毫升

反应性物质 人，老鼠，大鼠

寄主物种 兔

免疫原 一种衍生自人Tau的合成肽，围绕苏氨酸231的磷酸化位点

特 异性 磷酸化-Tau抗体（Thr231）仅在苏氨酸231磷酸化时检测Tau的内源性水平

纯化 该抗体来自纯化的兔血清，通过磷酸化和非磷酸肽亲和柱上的顺序色谱进行亲和纯化。

形式 兔IgG在磷酸盐缓冲盐水中，pH 7.4，150mM NaCl，0.02%叠氮化钠和50%甘油。储存在-20°C.自收到之日起可稳定保存12个月

基因名称 马普特

藏品编号 P10636

细胞通路/类别 一抗多克隆抗体

蛋白质分子量 78kDa

用法 仅供研究使用！不适用于诊断或治疗程序

来源：https://www.amyjet.com/products/GBS-ITA0919-100u.shtml