Arginine deiminase is a ~46 kDa protein that was isolated from the mycoplasma-contaminated cell culture. ADI can degrade arginine to citrulline and NHB3B. rADI has acted as a potent inhibitor of the growth of some arginine-dependent tumor in vitro and in vivo. rADI is expressed in E. coli and purified via Q-sepharose column.

Activity: The activity is assayed on anti-tumor cell in vitro.

Purity: ≥ 95% by SDS-PAGE.

M.W.: 46260

Ref.: Harasawa, R., et al. 1992. Microbiol. Immunol. 36, 661-665