Interleukin-6 is a prototypic pleiotrophic, pro-inflammatory cytokine that stimulates the production of acute phase proteins by hepatocytes. Also it is known to induce skeletal muscle protein breakdown. It can induce growth and differentiation of B cells, T cells, and hepatocytes, and stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B cell hybridoma 7TD1. IL-6 is produced by macrophages, endothelial cells, and activated T helper cells. It is also considered as a potential marker of adipocyte differentiation. Human IL-6 is active on murine cells. Recombinant interleukin-6 is expressed in E. coli.

Purity: ≥ 95% by SDS-PAGE.

M.W.: 23691

Ref: Braciak, T. A., et al. 1996. Protein Expr. Purif. 7, 269–274