Besides its neurotrophic properties, it has also been reported that PEDF is associated with senescence ａnd angiogenesis. The PEDF gene, termed EPC-1 (early population doubling level cDNA-1), is induced in young human fetal WI-38 lung fibroblasts cells upon entry into the G0 state, while senescent cells fail to express it.  It has binding affinity for glycosaminoglycans ａnd cell-surface receptors in cells that respond to its stimuli.  The overall protein conformation of PEDF resembles a member of the serine protease inhibitor (serpin) superfamily.  However, it does not inhibit known serine proteases ａnd its neurotrophic properties are independent of its protease inhibition potential.