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发布时间:2024/4/26点击次数:16
别名:2-Chloro-2,2-difluoro-1-phenyletha, Chlorodifluoromethyl phenyl ketone, α-Chloro-α,α-difluoroacehe
线性分子式:C6H5COCF2Cl
CAS号:384-67-8
分子量:190.57
Beilstein:2251448
MDL编号:MFCD00042123
PubChem化学物质编号:329768330
属性
质量水平
100
检测方案
95%
形式
liquid
reaction suitability
reaction type: C-C Bond Formation
折射率
n20/D 1.4954
n20/D 1.497 (lit.)
bp
94-96 °C/35 mmHg (lit.)
密度
1.293 g/mL at 25 °C (lit.)
1.3178 g/mL at 25 °C
SMILES string
FC(F)(Cl)C(=O)c1ccccc1
InChI
1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
InChI key
MNOONJNILVDLSW-UHFFFAOYSA-N
说明
一般描述
2-Chloro-2,2-difluoroacehe is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem -difluoromethene derived compounds.[1]
应用
2-Chloro-2,2-difluoroacehe can be used:
As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.[2]
As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.[3]
As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.[4]
Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.
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