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Anti-Interleukin 1 beta antibody Catalog Number:OM641709

发布时间:2024/8/22点击次数:12

 

Product Profile

Product Name Anti-Interleukin 1 beta antibody
Antibody Type Primary Antibodies
Immunogen
Polypeptide

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Human
Tested Applications

ELISAIHCWB

 
WB:1:200-1:2000
IHC:1:200-1:1000
Species Reactivity

GoatHumanMouseRat

Concentration 1.0mg/ml
Purification Protein A

Target Information

Gene Symbol IL1B interleukin 1 beta
Gene Synonyms
IL-1
IL1F2
IL1beta
IL1-BETA
More 
Gene Full Name interleukin 1 beta
Gene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly, IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2020]
More 
Molecular Weight(MW) 31 kDa
Source Rabbit
Cellular Localization Cylasm>Cytosol. Lysosome. Secreted>Extracellular exosome. Secreted.

Application

  • WB

    Western blot analysis using Interleukin 1 beta antibody against NIH 3T3 (1), K562 (2) cell lysate.

  • IHC

    Immunohistochemical analysis of paraffin-embedded bladder cancer tissues using Interleukin 1 beta antibody with DAB staining

Application Notes
WB:1:200-1:2000
IHC:1:200-1:1000

Additional Information

Form Liquid
Storage Instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer Purified antibody in PBS with 0.05% sodium azide.

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