The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins ａnd have numerous structural features in common. The most striking difference between RAP proteins ａnd RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs ａnd RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.1) Liu, C., et al. Mol. Cell. Biol. 30(16):3956-3969(2010)
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This RAP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-170 amino acids from the C-terminal region of human RAP1A.

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