P-V-Myb+C-Myb(S11) [SZ04-81] Catalog Number：OM637105_产品说明_ B2B电子商务综合技术文献

发布时间：2024/9/30点击次数：41

Product Name	P-V-Myb+C-Myb(S11) [SZ04-81]
Antibody Type	Primary Antibodies
Product description	The Myb family of transcription factors regulates proliferation, differentiation ａnd apoptosis of hemaoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear ａnd binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia ａnd transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, ａnd it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation ａnd may be essential for hemaoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes. More
Immunogen	Synthetic phospho-peptide corresponding to residues surrounding Ser11 of human V-Myb+C-Myb.

Alternative Names	C myb antibody C myb protein antibody Cmyb antibody MYB antibody Myb proto oncogene antibody V myb myeloblastosis viral oncogene homolog antibody
Molecular Weight(MW)	72/75 kDa
Cellular Localization	Nucleus.

SwissProt ID	P10242

Application

Fig1: ICC staining P-V-Myb+C-Myb(S11) in Ags cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application

Fig2: Immunohistochemical analysis of paraffin-embedded human uterine neck tissue using anti-P-V-Myb+C-Myb(S11) antibody. Counter stained with hematoxylin.
Application

Fig3: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-P-V-Myb+C-Myb(S11) antibody. Counter stained with hematoxylin.
Application

Fig4: Flow cytometric analysis of MCF-7 cells with P-V-Myb+C-Myb(S11) antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as antibody

Positive Control	Ags, human uterine neck tissue, human breast carcinoma tissue.
Application Notes	WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 More

Form	Liquid
Storage Instructions	Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

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